HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetohydrazide → 2'-Acetylamino-6'-(2-hydroxypropyl)-3'-methoxy-4-nitrobenzophenone acetylhydrazone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetohydrazide | HCID 14039 | — |
| Reactant | 6-Acetylamino-1-hydroxy-3-methyl-1-(4-nitrophenyl)-7-methoxyisochroman | HCID 22488968 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2'-Acetylamino-6'-(2-hydroxypropyl)-3'-methoxy-4-nitrobenzophenone acetylhydrazone | HCID 86584473 | 86.5% |
Reaction Steps
To a solution of 22 (1.7 g) in 25 ml of ethanol was added acetic hydrazide (0.5 g) and 2 drops of concentrated HCl. The resulting solution was refluxed for 3 hours. The solvent was removed under reduced pressure. The residue was treated with NaHCO3, and extracted with ethyl acetate. The combined organic phases were washed with brine, dried over Na2SO4. Removal of the solvent gave the desired product 23 (1.25 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06887867B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-8ee4d3da0e57482d9f98599d67594ed5 |
| Source note | uspto-grants-2005_05 |