反应详情

To a solution of 22 (1.7 g) in 25 ml of ethanol was added acetic hydrazide (0.5 g) and 2 drops of concentrated HCl. The resulting solution was refluxed for 3 hours. The solvent was removed under reduced pressure. The residue was treated with NaHCO3, and extracted with ethyl acetate. The combined organic phases were washed with brine, dried over Na2SO4. Removal of the solvent gave the desired product 23 (1.25 g).

1. temperatureThe resulting solution was refluxed for 3 hours
2. customThe solvent was removed under reduced pressure
3. additionThe residue was treated with NaHCO3
4. extractionextracted with ethyl acetate
5. washThe combined organic phases were washed with brine
6. dry with materialdried over Na2SO4
7. customRemoval of the solvent