HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2'-Acetylamino-6'-(2-methanesulfonyloxypropyl)-3'-methoxy-4-nitrobenzophenone acetylhydrazone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 2'-Acetylamino-6'-(2-hydroxypropyl)-3'-methoxy-4-nitrobenzophenone acetylhydrazone | HCID 86584473 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2'-Acetylamino-6'-(2-methanesulfonyloxypropyl)-3'-methoxy-4-nitrobenzophenone acetylhydrazone | HCID 86584474 | — |
Reaction Steps
To a solution of 23 (1.1 g) in 20 ml of CH2Cl2 was added 1.5 ml of triethyl amine, 0.60 ml of methanesulfonyl chloride at 0-10° C. After 30 min, no more starting material was detected on TLC. Water was added, extracted with CH2Cl2. The organic phase was washed with HCl (1N), brine, dried over Na2SO4. Removal of the solvent afforded product 24 (1.21 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06887867B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-fef2f01eefd34a739a8096f360924edc |
| Source note | uspto-grants-2005_05 |