反应详情

To a solution of 23 (1.1 g) in 20 ml of CH2Cl2 was added 1.5 ml of triethyl amine, 0.60 ml of methanesulfonyl chloride at 0-10° C. After 30 min, no more starting material was detected on TLC. Water was added, extracted with CH2Cl2. The organic phase was washed with HCl (1N), brine, dried over Na2SO4. Removal of the solvent afforded product 24 (1.21 g).

1. extractionextracted with CH2Cl2
2. washThe organic phase was washed with HCl (1N), brine
3. dry with materialdried over Na2SO4
4. customRemoval of the solvent