Methanesulfonic Acid → HCID 131724851, compound

HRID 2179911Notes

Reaction equation

HRID 2179911 reaction equation
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH3:6][N:7]([CH3:29])[CH:8]1[C:22]2=[CH:23][CH:19]([O:20][C:21]2=[O:24])[CH:18]2[CH:14]([O:15][C:16](=[O:26])[CH:17]2[CH3:25])[CH2:13][C:12]2([CH3:27])[CH:10]([O:11]2)[CH:9]1[OH:28]>CC(C)=O>[CH3:1][S:2]([O-:5])(=[O:4])=[O:3].[OH:28][CH:9]1[CH:8]([NH+:7]([CH3:6])[CH3:29])[C:22]2=[CH:23][CH:19]([O:20][C:21]2=[O:24])[CH:18]2[CH:14]([O:15][C:16](=[O:26])[CH:17]2[CH3:25])[CH2:13][C:12]2([CH3:27])[CH:10]1[O:11]2

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 86592994HCID 86592994, compound

Product 1

HCID 131724851HCID 131724851, compoundYield 55.4%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A solution of methanesulphonic acid (0.1 mmol; 1 ml; 0.1N in acetone) is added to a solution of the compound of Example 5 (0.1 mmol; 34 mg) in acetone (2 ml). The precipitate is filtered, washed with acetone and dried under reduced pressure. 24 mg of the expected product is obtained in the form of a white powder. Melting point: 220° C.

Workup

  1. filtrationThe precipitate is filtered
  2. washwashed with acetone
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-b68bc0b6d2554ef7ae374df5794cab9f
Source dataset
uspto-grants-2005_05
Patent number
US06887869B2

Reaction notes

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