Ethyl chloroformate → HCID 73207753, compound

HRID 2179915Notes

Reaction equation

HRID 2179915 reaction equation
Cl[C:2]([O:4][CH2:5][CH3:6])=[O:3].[OH:7][CH:8]1[CH:22]([N:23]2[CH2:28][CH2:27][CH:26]([CH3:29])[CH2:25][CH2:24]2)[C:21]2=[CH:30][CH:18]([O:19][C:20]2=[O:31])[CH:17]2[CH:13]([O:14][C:15](=[O:33])[CH:16]2[CH3:32])[CH2:12][C:11]2([CH3:34])[CH:9]1[O:10]2.C(OC1C(N2CCC(C)CC2)C2=CC(OC2=O)C2C(OC(=O)C2C)CC2(C)C1O2)(=O)C>N1C=CC=CC=1>[C:2](=[O:3])([O:7][CH:8]1[CH:22]([N:23]2[CH2:28][CH2:27][CH:26]([CH3:29])[CH2:25][CH2:24]2)[C:21]2=[CH:30][CH:18]([O:19][C:20]2=[O:31])[CH:17]2[CH:13]([O:14][C:15](=[O:33])[CH:16]2[CH3:32])[CH2:12][C:11]2([CH3:34])[CH:9]1[O:10]2)[O:4][CH2:5][CH3:6]

Participants

5

Reactant 3

HCID 10928Ethyl chloroformateHCID 73207834HCID 73207834, compoundHCID 73207857HCID 73207857, compound

Product 1

HCID 73207753HCID 73207753, compoundYield 43.1%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Ethyl chloroformate (300 μmol; 28 μl) is added to a solution of the compound of Example 9 (100 μmol; 40 mg) in pyridine (0.5 ml). The reaction mass is stirred for 2 hours then treated in the same manner as for the preparation of the compound of Example 17. 20 mg of product is obtained in the form of a white powder.

Sources & evidence

ORD record
ord-40eac1d7e427410ea8c63f69b0b54737
Source dataset
uspto-grants-2005_05
Patent number
US06887869B2

Reaction notes

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