HRID2179915

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10928

Ethyl chloroformate

C3H5ClO2

结构：CC1CCN(C2C3=CC(OC3=O)C3C(CC4(C)OC4C2O)OC(=O)C3C)CC1

HCID73207834

未命名化合物

结构：CC(=O)OC1C(N2CCC(C)CC2)C2=CC(OC2=O)C2C(CC3(C)OC13)OC(=O)C2C

HCID73207857

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)OC1C(N2CCC(C)CC2)C2=CC(OC2=O)C2C(CC3(C)OC13)OC(=O)C2C

HCID73207753

未命名化合物

收率 43.1%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

Ethyl chloroformate (300 μmol; 28 μl) is added to a solution of the compound of Example 9 (100 μmol; 40 mg) in pyridine (0.5 ml). The reaction mass is stirred for 2 hours then treated in the same manner as for the preparation of the compound of Example 17. 20 mg of product is obtained in the form of a white powder.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-40eac1d7e427410ea8c63f69b0b54737
来源数据集: uspto-grants-2005_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06887869B2
来源说明: uspto-grants-2005_05

反应 SMILES

Cl[C:2]([O:4][CH2:5][CH3:6])=[O:3].[OH:7][CH:8]1[CH:22]([N:23]2[CH2:28][CH2:27][CH:26]([CH3:29])[CH2:25][CH2:24]2)[C:21]2=[CH:30][CH:18]([O:19][C:20]2=[O:31])[CH:17]2[CH:13]([O:14][C:15](=[O:33])[CH:16]2[CH3:32])[CH2:12][C:11]2([CH3:34])[CH:9]1[O:10]2.C(OC1C(N2CCC(C)CC2)C2=CC(OC2=O)C2C(OC(=O)C2C)CC2(C)C1O2)(=O)C>N1C=CC=CC=1>[C:2](=[O:3])([O:7][CH:8]1[CH:22]([N:23]2[CH2:28][CH2:27][CH:26]([CH3:29])[CH2:25][CH2:24]2)[C:21]2=[CH:30][CH:18]([O:19][C:20]2=[O:31])[CH:17]2[CH:13]([O:14][C:15](=[O:33])[CH:16]2[CH3:32])[CH2:12][C:11]2([CH3:34])[CH:9]1[O:10]2)[O:4][CH2:5][CH3:6]