2,4-Dichlorobenzotrifluoride → gamma-[5-Chloro-2-(trifluoromethyl)phenoxy]-N-methylbenzenepropanamine hydrochloride

HRID 2179947Notes

Reaction equation

HRID 2179947 reaction equation
[Cl:1]C1C(F)=CC(C#N)=C(O[C@@H](C2C=CC=CC=2)CCI)C=1.CC(O[C:27](=O)[NH:28][CH2:29][CH2:30][CH:31]([OH:38])[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)(C)C.Cl[C:41]1[CH:46]=[C:45]([Cl:47])[CH:44]=[CH:43][C:42]=1[C:48]([F:51])([F:50])[F:49]>>[ClH:1].[Cl:47][C:45]1[CH:46]=[CH:41][C:42]([C:48]([F:49])([F:50])[F:51])=[C:43]([CH:44]=1)[O:38][CH:31]([C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1)[CH2:30][CH2:29][NH:28][CH3:27]

Participants

4

Reactant 3

HCID 94432,4-DichlorobenzotrifluorideHCID 15431788tert-Butyl (3-hydroxy-3-phenylpropyl)carbamateHCID 697986504-Chloro-5-fluoro-2-{[(1R)-3-iodo-1-phenylpropyl]oxy}benzonitrile

Product 1

HCID 22489955gamma-[5-Chloro-2-(trifluoromethyl)phenoxy]-N-methylbenzenepropanamine hydrochloride

Procedure

The title compound was prepared by the method of Example 3 (b) using racemic (3-hydroxy-3-phenylpropyl)carbamic acid 1,1-dimethylethyl ester and 2,4-dichloro-1-(trifluoromethyl)benzene to give 70 mg of the product as a colourless solid.

Sources & evidence

ORD record
ord-7cedfcb1980240f7875e2129062b5824
Source dataset
uspto-grants-2005_05
Patent number
US06887871B2

Reaction notes

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