反应详情

4-Chloro-2-{[(1R)-3-chloro-1-phenylpropyl]oxy}-5-fluorobenzonitrile (1.8 , 5.6 mmol) and sodium iodide (12.8 g, 100 mmol) were dissolved in acetone (50 ml) and heated under reflux for 24 h. The reaction mixture was cooled, filtered and evaporated. The semi-solid residue was dissolved in toluene, filtered and evaporated again to give 2.3 g of the crude product as a yellow oil. This was used without purification for the next step.

1. temperatureheated
2. temperatureunder reflux for 24 h
3. temperatureThe reaction mixture was cooled
4. filtrationfiltered
5. customevaporated
6. dissolutionThe semi-solid residue was dissolved in toluene
7. filtrationfiltered
8. customevaporated again