4-Chloro-2,5-difluorobenzonitrile → (3-(5-Chloro-2-cyano-4-fluorophenoxy)-3-(6-methoxy-2-pyridinyl)-propyl]-carbamic acid 1,1-dimethylethyl ester

HRID 2179961Notes

Reaction equation

HRID 2179961 reaction equation
[CH3:1][C:2]([O:5][C:6](=[O:20])[NH:7][CH2:8][CH2:9][CH:10]([OH:19])[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[N:12]=1)([CH3:4])[CH3:3].[Cl:21][C:22]1[C:29]([F:30])=[CH:28][C:25]([C:26]#[N:27])=[C:24](F)[CH:23]=1>>[CH3:4][C:2]([O:5][C:6](=[O:20])[NH:7][CH2:8][CH2:9][CH:10]([O:19][C:24]1[CH:23]=[C:22]([Cl:21])[C:29]([F:30])=[CH:28][C:25]=1[C:26]#[N:27])[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[N:12]=1)([CH3:1])[CH3:3]

Participants

3

Reactant 2

HCID 112753024-Chloro-2,5-difluorobenzonitrileHCID 69798380[3-Hydroxy-3-(6-methoxy-2-pyridinyl)propyl]carbamic acid 1,1-dimethylethyl ester

Product 1

HCID 86759697(3-(5-Chloro-2-cyano-4-fluorophenoxy)-3-(6-methoxy-2-pyridinyl)-propyl]-carbamic acid 1,1-dimethylethyl ester

Procedure

The sub-title compound was prepared by the method of Example 58 (c) using [3-hydroxy-3-(6-methoxy-2-pyridinyl)propyl]carbamic acid 1,1-dimethylethyl ester (Example 61 (b)) and 4-chloro-2,5-difluorobenzonitrile.

Sources & evidence

ORD record
ord-de17b066fe074c6f96274055290c3e24
Source dataset
uspto-grants-2005_05
Patent number
US06887871B2

Reaction notes

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