Hydrochloric Acid → 3-Chloro-1-(3-isoxazolyl)-1-propanone

HRID 2179987Notes

Reaction equation

HRID 2179987 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6](=[O:9])[CH:7]=[CH2:8])=[N:2]1.[ClH:10]>CCOCC>[Cl:10][CH2:8][CH2:7][C:6]([C:3]1[CH:4]=[CH:5][O:1][N:2]=1)=[O:9]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 224899521-(3-Isoxazolyl)-2-propen-1-one

Product 1

HCID 224890493-Chloro-1-(3-isoxazolyl)-1-propanone

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The product of step (b) was treated with 1M HCl in ether (5 ml) and stirred for 4 h at ambient temperature. The solvent was then removed under reduced pressure to leave the product as a dark gum (0.42 g).

Workup

  1. customThe solvent was then removed under reduced pressure

Sources & evidence

ORD record
ord-734f46ae7d784cbf84eac67a815bea78
Source dataset
uspto-grants-2005_05
Patent number
US06887871B2

Reaction notes

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