HCID 22490258, compound → HCID 22490257, compound

HRID 2180019Notes

Reaction equation

HRID 2180019 reaction equation
[C:1]([C:3]1[CH:23]=[CH:22][C:6]([O:7][CH2:8][CH:9]2[CH2:11][N:10]2[C:12]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:13])=[CH:5][CH:4]=1)#[N:2].[CH:24]12[CH2:32][CH:28]([CH2:29][NH:30][CH2:31]1)[CH2:27][N:26]([C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])[CH2:25]2>C(O)(C)C>[CH2:15]([O:14][C:12]([NH:10][CH:9]([CH2:8][O:7][C:6]1[CH:5]=[CH:4][C:3]([C:1]#[N:2])=[CH:23][CH:22]=1)[CH2:11][N:30]1[CH2:31][CH:24]2[CH2:32][CH:28]([CH2:27][N:26]([C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])[CH2:25]2)[CH2:29]1)=[O:13])[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 22490258HCID 22490258, compoundHCID 22490264Tert-butyl 3,7-diazabicyclo(3.3.1)nonane-3-carboxylate

Product 1

HCID 22490257HCID 22490257, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
60 °C

Procedure

Benzyl 2-[(4-cyanophenoxy)methyl]-1-aziridinecarboxylate (1.0 g; 3.2 mmol; from step (iii) above) was mixed with tert-butyl 3,7-diazabicyclo[3.3.1]nonane-3-carboxylate (from step (v) above; 0.73 g; 3.2 mmol) and 30 mL of iso-propanol, and stirred at 60° C. for 5 h, and then at rt overnight. The solvent was evaporated and the crude material was purified on silica (DCM:5% MeOH) yielding 1.3 g (76%) of sub-title compound.

Workup

  1. customat rt
  2. customovernight
  3. customThe solvent was evaporated
  4. customthe crude material was purified on silica (DCM:5% MeOH)

Sources & evidence

ORD record
ord-eb57c66ba75f4db1bdf6bf4fea04157e
Source dataset
uspto-grants-2005_05
Patent number
US06887881B1

Reaction notes

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