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HRID2180033

反应详情

EQUATION

反应方程式

HRID 2180033 的结构方程式

REACTANTS

反应物

2
结构：Nc1ccc(F)c(Br)c1
HCID2779286

3-Bromo-4-fluoroaniline

C6H5BrFN

结构：Cn1ccc(Cl)c([N+](=O)[O-])c1=O
HCID22490301

未命名化合物

PRODUCTS

生成物

1
结构：Cn1ccc(Nc2ccc(F)c(Br)c2)c([N+](=O)[O-])c1=O
HCID22490299

4-[(3-Bromo-4-fluorophenyl)amino]-1-methyl-3-nitro-2(1H)-pyridinone

C12H9BrFN3O3

收率 40%

PROCEDURE

实验过程

4-Chloro-1-methyl-3-nitro-1H-pyridin-2-one was coupled to 3-bromo-4-fluorophenylamine, in the same way as in Example 1, to give 4-(3-bromo-4-fluorophenylamino)-1-methyl-3-nitro-1H-pyridin-2-one as a beige solid (2.0 g, 40%): δH (400 MHz, d6-DMSO) 3.36 (3H, s), 5.81 (1H, d, J 8), 7.33-7.37 (1H, m), 7.45 (1H, t, J 9), 7.64-7.68 (1H, m), 7.66 (1H, s), 9.73 (1H, s).