HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-4-fluoroaniline → 4-(3-bromo-4-fluorophenylamino)-1-methyl-3-nitro-1H-pyridin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-4-fluoroaniline | HCID 2779286 | — |
| Reactant | 4-Chloro-1-methyl-3-nitro-1,2-dihydropyridin-2-one | HCID 22490301 | — |
| Product | 4-(3-bromo-4-fluorophenylamino)-1-methyl-3-nitro-1H-pyridin-2-one | HCID 22490299 | 40% |
Reaction Steps
4-Chloro-1-methyl-3-nitro-1H-pyridin-2-one was coupled to 3-bromo-4-fluorophenylamine, in the same way as in Example 1, to give 4-(3-bromo-4-fluorophenylamino)-1-methyl-3-nitro-1H-pyridin-2-one as a beige solid (2.0 g, 40%): δH (400 MHz, d6-DMSO) 3.36 (3H, s), 5.81 (1H, d, J 8), 7.33-7.37 (1H, m), 7.45 (1H, t, J 9), 7.64-7.68 (1H, m), 7.66 (1H, s), 9.73 (1H, s).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06887885B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-ff51c422c8ab470fa68f4e6b998d53aa |
| Source note | uspto-grants-2005_05 |