反应详情

温度

0 °C

A solution of Example 1A (25.8 g,100 mmol), sulfur trioxide pyridine complex (79.6 g, 500 mmol), and triethylamine (69.7 mL, 500 mmol) in DMSO (70 mL) at room temperature was stirred for 30 minutes, cooled to 0° C., treated with water and saturated aqueous KHSO4, and extracted with ethyl acetate. The extract was washed with saturated aqueous KHSO4 and brine, dried (MgSO4), filtered, and concentrated to provide the desired product.

1. extractionextracted with ethyl acetate
2. washThe extract was washed with saturated aqueous KHSO4 and brine
3. dry with materialdried (MgSO4)
4. filtrationfiltered
5. concentrationconcentrated