反应详情

温度

85 °C

A solution of Example 14A (0.064 g, 0.20 mmol) in ethanol (3 mL) was treated with pyridine (2 mL) and 4-chlorobenzaldehyde (0.033 mL, 0.23 mmol), heated to 85° C., stirred for 16 hours, and concentrated. The concentrate was purified by flash column chormatography on silica gel with ethyl acetate in hexanes, and the purified concntrate was treated with 4N HCl in dioxane, stirred for 4 hours, concentrated, precipitated from diethyl ether, and collected by filtration to provide the desired product.

1. concentrationconcentrated
2. customThe concentrate was purified by flash column chormatography on silica gel with ethyl acetate in hexanes
3. additionthe purified concntrate was treated with 4N HCl in dioxane
4. stirringstirred for 4 hours
5. concentrationconcentrated
6. customprecipitated from diethyl ether
7. filtrationcollected by filtration