HCID 91018032, compound → HCID 87999122, compound

HRID 2180234Notes

Reaction equation

HRID 2180234 reaction equation
[C:1]([O:5][C:6]([NH:8][C@H:9]([CH2:27][CH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1)[CH:10]([OH:26])[C:11]([NH:13][O:14][CH2:15][C:16]([O:18]CC1C=CC=CC=1)=[O:17])=[O:12])=[O:7])([CH3:4])([CH3:3])[CH3:2]>[Pd].C1COCC1>[C:1]([O:5][C:6]([NH:8][C@H:9]([CH2:27][CH:28]1[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]1)[CH:10]([OH:26])[C:11]([NH:13][O:14][CH2:15][C:16]([OH:18])=[O:17])=[O:12])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 91018032HCID 91018032, compound

Product 1

HCID 87999122HCID 87999122, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A solution of Example 117A (0.99 g, 2.1 mmol), and 10% Palladium on charcoal (0.21 g) in THF (10 mL) at room temperature was stirred for 4 hours under an atmosphere of hydrogen gas, filtered, and concentrated to provide the desired product.

Workup

  1. filtrationfiltered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-f5cc9327e7db4598a70525664c499a10
Source dataset
uspto-grants-2005_05
Patent number
US06887863B2

Reaction notes

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