1-Methylpiperazine → 3-(N-methylpiperazinyl)propylphthalimide

HRID 21804Notes

Reaction equation

HRID 21804 reaction equation
Br[CH2:2][CH2:3][CH2:4][C:5]1[CH:15]=[CH:14][CH:13]=[C:7]2[C:8]([NH:10][C:11](=[O:12])[C:6]=12)=[O:9].[CH3:16][N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1>C(OCC)C>[CH3:16][N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH:18]1[CH2:2][CH2:3][CH2:4][C:5]1[CH:15]=[CH:14][CH:13]=[C:7]2[C:8]([NH:10][C:11](=[O:12])[C:6]=12)=[O:9]

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 21958088Bromopropylphthalimide

Product 1

HCID 537877233-(N-methylpiperazinyl)propylphthalimide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

3-Bromopropylphthalimide (536 mg; 2.0 mmoles) and N-methylpiperazine (0.44 ml; 4.0 mmoles) were dissolved in anhydrous ethyl ether (5 ml). Reaction times and process as per Example 1.

Workup

  1. customReaction times and process as per Example 1

Sources & evidence

ORD record
ord-521cacb8467e4003a1a697692b9ed1bf
Source dataset
uspto-grants-1995_06
Patent number
US05424451

Reaction notes

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