Dichloromethane → HCID 73989424, compound

HRID 2180400Notes

Reaction equation

HRID 2180400 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][NH:8][S:9]([C:12]2[CH:13]=[C:14]([CH:18]=[CH:19][C:20]([OH:22])=O)[CH:15]=[CH:16][CH:17]=2)(=[O:11])=[O:10])[CH:2]=1.[Cl:23]CCl>CN(C)C=O>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][NH:8][S:9]([C:12]2[CH:13]=[C:14]([CH:18]=[CH:19][C:20]([Cl:23])=[O:22])[CH:15]=[CH:16][CH:17]=2)(=[O:11])=[O:10])[CH:2]=1

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 67019629HCID 67019629, compound

Product 1

HCID 73989424HCID 73989424, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideCatalyst

Conditions

Temperature
40 °C

Procedure

To a suspension of 3-{3-[(pyridin-3-ylmethyl)-sulfamoyl]-phenyl}-acrylic acid (15b) (0.28 g, 0.88 mmol) in dichloromethane (3.5 ml) oxalyl chloride (0.23 ml, 2.64 mmol) and one drop of dimethylformamide were added. The reaction mixture was stirred at 40° C. for one hour and concentrated under reduced pressure to give crude title compound (0.29 g, 98%).

Workup

  1. additionwere added
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-ddb2594a36d04deba53763c65e6cd3ef
Source dataset
uspto-grants-2005_05
Patent number
US06888027B2

Reaction notes

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