Sodium Hydroxide → HCID 60003043, compound

HRID 2180474Notes

Reaction equation

HRID 2180474 reaction equation
[CH2:1]([O:3][C:4]1[CH:13]=[C:12]2[C:7]([C:8]([CH2:16][CH3:17])=[CH:9][C:10]([CH3:15])([CH3:14])[O:11]2)=[CH:6][C:5]=1/[C:18](/[CH3:30])=[CH:19]\[CH:20]=[CH:21]\[C:22](\[CH3:29])=[CH:23]\[C:24]([O:26]CC)=[O:25])[CH3:2].[OH-].[Na+]>>[CH2:1]([O:3][C:4]1[CH:13]=[C:12]2[C:7]([C:8]([CH2:16][CH3:17])=[CH:9][C:10]([CH3:15])([CH3:14])[O:11]2)=[CH:6][C:5]=1/[C:18](/[CH3:30])=[CH:19]\[CH:20]=[CH:21]\[C:22](\[CH3:29])=[CH:23]\[C:24]([OH:26])=[O:25])[CH3:2]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 87973066HCID 87973066, compound

Product 1

HCID 60003043HCID 60003043, compound

Procedure

Following General Procedure G, ethyl 7-(7-ethoxy-4-ethyl-2,2-dimethyl-2H-chromen-6-yl)-3-methyl-octa-2E,4E,6Z-trienoate (Compound 35,23 mg, 0.058 mmol) was hydrolyzed with 1M NaOH. Purification by column chromatography (silica gel, 30% ethyl acetate in hexanes) followed by recrystallization from acetonitrile gave rise to the title compound as a light yellow solid.

Workup

  1. customPurification by column chromatography (silica gel, 30% ethyl acetate in hexanes)
  2. customfollowed by recrystallization from acetonitrile

Sources & evidence

ORD record
ord-7678877f4a414dec857e7c6bf4ed95ce
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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