Stannane, tributyl(1-ethoxyethenyl)- → 1-(4-Isopropyl-7-methoxy-2,2-dimethyl-2H-chromen-6-yl)-ethanone

HRID 2180480Notes

Reaction equation

HRID 2180480 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[O:8][C:7]([CH3:15])([CH3:14])[CH:6]=[C:5]2[CH:16]([CH3:18])[CH3:17].C([Sn](CCCC)(CCCC)[C:24]([O:26]CC)=[CH2:25])CCC>C1COCC1>[CH:16]([C:5]1[C:4]2[C:9](=[CH:10][C:11]([O:12][CH3:13])=[C:2]([C:24](=[O:26])[CH3:25])[CH:3]=2)[O:8][C:7]([CH3:15])([CH3:14])[CH:6]=1)([CH3:18])[CH3:17]

Participants

4

Reactant 2

HCID 619414Stannane, tributyl(1-ethoxyethenyl)-HCID 224908876-bromo-4-isopropyl-7-methoxy-2,2-dimethyl-2H-chromene2×

Product 1

HCID 224908471-(4-Isopropyl-7-methoxy-2,2-dimethyl-2H-chromen-6-yl)-ethanone

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following General Procedure H, a solution of 6-bromo-4-isopropyl-7-methoxy-2,2-dimethyl-2H-chroman-4-one (Compound 14, 290 mg, 0.94 mmol) in THF was treated with tributyl(1-ethoxyvinyl)tin (0.63 mL, 1.88 mmol) to give the title compound as a colorless oil.

Sources & evidence

ORD record
ord-88a9276e47004e97829de70fa6e648e2
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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