Stannane, tributyl(1-ethoxyethenyl)- → 1-(4-tert-Butyl-7-methoxy-2,2-dimethyl-2H-chromen-6-yl)-ethanone

HRID 2180481Notes

Reaction equation

HRID 2180481 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[O:8][C:7]([CH3:15])([CH3:14])[CH:6]=[C:5]2[C:16]([CH3:19])([CH3:18])[CH3:17].C([Sn](CCCC)(CCCC)[C:25]([O:27]CC)=[CH2:26])CCC>C1COCC1>[C:16]([C:5]1[C:4]2[C:9](=[CH:10][C:11]([O:12][CH3:13])=[C:2]([C:25](=[O:27])[CH3:26])[CH:3]=2)[O:8][C:7]([CH3:15])([CH3:14])[CH:6]=1)([CH3:19])([CH3:18])[CH3:17]

Participants

4

Reactant 2

HCID 619414Stannane, tributyl(1-ethoxyethenyl)-HCID 224909336-Bromo-4-tert-butyl-7-methoxy-2,2-dimethyl-2H-chromene2×

Product 1

HCID 224907731-(4-tert-Butyl-7-methoxy-2,2-dimethyl-2H-chromen-6-yl)-ethanone

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following General Procedure H, a solution of 6-bromo-4-tert-butyl-7-methoxy-2,2-dimethyl-2H-chromene (Compound 15, 280 mg, 0.86 mmol) in THF was treated with tributyl(1-ethoxyvinyl)tin (0.58 mL, 1.7 mmol) to give the title compound as a colorless oil.

Sources & evidence

ORD record
ord-3349ccbf6fdc4ec7b451d0617e27d7ca
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

Loading…