Triethyl 2-fluoro-2-phosphonoacetate → HCID 86597834, compound

HRID 2180495Notes

Reaction equation

HRID 2180495 reaction equation
[CH3:1][CH2:2][O:3][C:4]([CH:6](P(OCC)(OCC)=O)[F:7])=[O:5].[CH2:16]([O:18][C:19]1[CH:28]=[C:27]2[C:22]([C:23]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)=[CH:24][C:25]([CH3:30])([CH3:29])[O:26]2)=[CH:21][C:20]=1[C:37](=O)[CH3:38])[CH3:17]>>[CH2:16]([O:18][C:19]1[CH:28]=[C:27]2[C:22]([C:23]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)=[CH:24][C:25]([CH3:29])([CH3:30])[O:26]2)=[CH:21][C:20]=1/[C:37](/[CH3:38])=[C:6](/[F:7])\[C:4]([O:3][CH2:2][CH3:1])=[O:5])[CH3:17]

Participants

3

Reactant 2

HCID 2734865Triethyl 2-fluoro-2-phosphonoacetateHCID 224910931-(7-Ethoxy-2,2-dimethyl-4-phenyl-2H-chromen-6-yl)-ethanone2×

Product 1

HCID 86597834HCID 86597834, compound

Procedure

Following General Procedure K, triethyl-2-fluoro-2-phosphonoacetate (0.42 mL, 1.70 mmol) and 1-(7-ethoxy-2,2-dimethyl-4-phenyl-2H-chromen-6-yl)-ethanone (Compound 66, 183 mg, 0.57 mmol) were reacted to give the title compound as a colorless oil after purification by flash chromatography (silica gel, 1:9 ethyl acetate/hexane).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-c809fb5dde6943cbafb8df1e299c6eed
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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