Methyl morpholine oxide → HCID 22490769, compound

HRID 2180513Notes

Reaction equation

HRID 2180513 reaction equation
[CH2:1]([O:3][C:4]1[CH:13]=[C:12]2[C:7]([C:8]([CH:16]([CH3:18])[CH3:17])=[CH:9][C:10]([CH3:15])([CH3:14])[O:11]2)=[CH:6][C:5]=1/[C:19](/[CH3:24])=[C:20](/[F:23])\[CH2:21][OH:22])[CH3:2].C[N+]1([O-])CCOCC1>>[CH2:1]([O:3][C:4]1[CH:13]=[C:12]2[C:7]([C:8]([CH:16]([CH3:17])[CH3:18])=[CH:9][C:10]([CH3:14])([CH3:15])[O:11]2)=[CH:6][C:5]=1/[C:19](/[CH3:24])=[C:20](/[F:23])\[CH:21]=[O:22])[CH3:2]

Participants

3

Reactant 2

HCID 82029Methyl morpholine oxideHCID 22490831HCID 22490831, compound2×

Product 1

HCID 22490769HCID 22490769, compound

Procedure

Following General Procedure M, (2E)-3-(7-ethoxy-4-isopropyl-2,2-dimethyl-2H-chromen-6-yl)-2-fluoro-but-2-en-1-ol (Compound 85, 114 mg, 0.36 mmol) and 4-methylmorpholine N-oxide (85 mg, 0.72 mmol) were reacted to give the title compound as a yellow oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-58ea152a1319495ea8c645b5e84b0e82
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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