Methyl morpholine oxide → HCID 22490877, compound

HRID 2180514Notes

Reaction equation

HRID 2180514 reaction equation
[F:1]/[C:2](=[C:5](/[C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][C:16]=1[O:17][CH2:18][CH2:19][CH3:20])[O:13][C:12]([CH3:22])([CH3:21])[CH:11]=[C:10]2[CH:23]([CH3:25])[CH3:24])\[CH3:6])/[CH2:3][OH:4].C[N+]1([O-])CCOCC1>>[F:1]/[C:2](=[C:5](/[C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][C:16]=1[O:17][CH2:18][CH2:19][CH3:20])[O:13][C:12]([CH3:22])([CH3:21])[CH:11]=[C:10]2[CH:23]([CH3:24])[CH3:25])\[CH3:6])/[CH:3]=[O:4]

Participants

3

Reactant 2

HCID 82029Methyl morpholine oxideHCID 22490954HCID 22490954, compound2×

Product 1

HCID 22490877HCID 22490877, compound

Procedure

Following General Procedure M, (2E)-2-fluoro-3-(4-isopropyl-2,2-dimethyl-7-propoxy-2H-chromen-6-yl)-but-2-en-1-ol (Compound 86, 100 mg, 0.27 mmol) and 4-methylmorpholine N-oxide (75 mg, 0.57 mmol) were reacted to give the title compound as a yellow oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-d6d6869a68dd42e9a53903353c296ce4
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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