Methyl morpholine oxide → (2E)-3-(7-Butoxy-4-isopropyl-2,2-dimethyl-2H-chromen-6-yl)-2-fluoro-but-2-enal

HRID 2180515Notes

Reaction equation

HRID 2180515 reaction equation
[CH2:1]([O:5][C:6]1[CH:15]=[C:14]2[C:9]([C:10]([CH:18]([CH3:20])[CH3:19])=[CH:11][C:12]([CH3:17])([CH3:16])[O:13]2)=[CH:8][C:7]=1/[C:21](/[CH3:26])=[C:22](/[F:25])\[CH2:23][OH:24])[CH2:2][CH2:3][CH3:4].C[N+]1([O-])CCOCC1>>[CH2:1]([O:5][C:6]1[CH:15]=[C:14]2[C:9]([C:10]([CH:18]([CH3:19])[CH3:20])=[CH:11][C:12]([CH3:17])([CH3:16])[O:13]2)=[CH:8][C:7]=1/[C:21](/[CH3:26])=[C:22](/[F:25])\[CH:23]=[O:24])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 82029Methyl morpholine oxideHCID 22490857(2E)-3-(7-Butoxy-4-isopropyl-2,2-dimethyl-2H-chromen-6-yl)-2-fluoro-but-2-en-1-ol2×

Product 1

HCID 22490854(2E)-3-(7-Butoxy-4-isopropyl-2,2-dimethyl-2H-chromen-6-yl)-2-fluoro-but-2-enal

Procedure

Following General Procedure M, (2E)-3-(7-butoxy 4-isopropyl-2,2-dimethyl-2H-chromen-6-yl)-2-fluoro-but-2-en-1-ol (Compound 87, 109 mg, 0.30 mmol) and 4-methylmorpholine N-oxide (70 mg, 0.60 mmol) were reacted to give the title compound as a yellow oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-83654ea74b5a4f0186e4bf3fcb22ba88
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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