Methyl morpholine oxide → HCID 22490770, compound

HRID 2180517Notes

Reaction equation

HRID 2180517 reaction equation
[CH3:1][C:2]1([CH3:28])[CH:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][C:6]([O:24][CH2:25][CH2:26][CH3:27])=[C:7](/[C:18](/[CH3:23])=[C:19](/[F:22])\[CH2:20][OH:21])[CH:8]=2)[O:3]1.C[N+]1([O-])CCOCC1>>[CH3:1][C:2]1([CH3:28])[CH:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][C:6]([O:24][CH2:25][CH2:26][CH3:27])=[C:7](/[C:18](/[CH3:23])=[C:19](/[F:22])\[CH:20]=[O:21])[CH:8]=2)[O:3]1

Participants

3

Reactant 2

HCID 82029Methyl morpholine oxideHCID 22490820HCID 22490820, compound2×

Product 1

HCID 22490770HCID 22490770, compound

Procedure

Following General Procedure M, (2E)-3-(2,2-dimethyl-4-phenyl-7-propoxy-2H-chromen-6-yl)-2-fluoro-but-2-en-1-ol (Compound 89, 145 mg, 0.38 mmol) and 4-methylmorpholine N-oxide (90 mg, 0.76 mmol) were reacted to give the title compound as a yellow oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-f0793fcd035e42538086c0c806269f55
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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