Ethyl 4-(diethoxyphosphoryl)-3-methylbut-2-enoate → HCID 131724861, compound

HRID 2180519Notes

Reaction equation

HRID 2180519 reaction equation
C(OP([CH2:9]/[C:10](/[CH3:17])=[CH:11]/[C:12]([O:14][CH2:15][CH3:16])=[O:13])(OCC)=O)C.[CH2:18]([O:20][C:21]1[CH:30]=[C:29]2[C:24]([C:25]([CH:33]([CH3:35])[CH3:34])=[CH:26][C:27]([CH3:32])([CH3:31])[O:28]2)=[CH:23][C:22]=1/[C:36](/[CH3:41])=[C:37](/[F:40])\[CH:38]=O)[CH3:19]>>[CH2:18]([O:20][C:21]1[CH:30]=[C:29]2[C:24]([C:25]([CH:33]([CH3:35])[CH3:34])=[CH:26][C:27]([CH3:32])([CH3:31])[O:28]2)=[CH:23][C:22]=1/[C:36](/[CH3:41])=[C:37](/[F:40])\[CH:38]=[CH:9]\[C:10](\[CH3:17])=[CH:11]\[C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH3:19]

Participants

3

Reactant 2

HCID 6000084Ethyl 4-(diethoxyphosphoryl)-3-methylbut-2-enoateHCID 22490769HCID 22490769, compound2×

Product 1

HCID 131724861HCID 131724861, compound

Procedure

Following General Procedure O, ethyl 4-(diethoxyphosphoryl)-3-methyl-but-2E-enoate (230 mg, 0.84 mmol) and (2E)-3-(7-ethoxy-4-isopropyl-2,2-dimethyl-2H-chromen-6-yl)-2-fluoro-but-2-enal (Compound 98, 96 mg, 0.29 mmol) were reacted to give the title compound as a yellow oil after purification by column chromatography (silica gel, 5% ethyl acetate in hexane).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-776216f478f4469fb62780916edb8d0b
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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