Sodium Hydroxide → HCID 60003046, compound

HRID 2180532Notes

Reaction equation

HRID 2180532 reaction equation
[F:1]/[C:2](=[C:13](/[C:16]1[CH:17]=[C:18]2[C:23](=[CH:24][C:25]=1[O:26][CH3:27])[O:22][C:21]([CH3:29])([CH3:28])[CH:20]=[C:19]2[CH:30]([CH3:32])[CH3:31])\[CH2:14][CH3:15])/[CH:3]=[CH:4]/[C:5](/[CH3:12])=[CH:6]/[C:7]([O:9]CC)=[O:8].[OH-].[Na+]>C(O)C.C1COCC1>[F:1]/[C:2](=[C:13](/[C:16]1[CH:17]=[C:18]2[C:23](=[CH:24][C:25]=1[O:26][CH3:27])[O:22][C:21]([CH3:29])([CH3:28])[CH:20]=[C:19]2[CH:30]([CH3:31])[CH3:32])\[CH2:14][CH3:15])/[CH:3]=[CH:4]/[C:5](/[CH3:12])=[CH:6]/[C:7]([OH:9])=[O:8]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 87972666HCID 87972666, compound2×

Product 1

HCID 60003046HCID 60003046, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

Following General Procedure G, a solution of ethyl 6-fluoro-7-(4-isopropyl-7-methoxy-2,2-dimethyl-2H-chromen-6-yl)3-methyl-nona-2E,4E,6E-trienoate (Compound 117, 86 mg, 0.20 mmol) in ethanol and THF was hydrolyzed with 1M NaOH. Purification by flash chromatography (silica gel, 75:25 hexane/ethyl acetate) afforded the title compound as a light yellow solid.

Workup

  1. customPurification by flash chromatography (silica gel, 75:25 hexane/ethyl acetate)

Sources & evidence

ORD record
ord-ebc9400d577e481ca7614a051a0cdc7e
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

Loading…