Methyl morpholine oxide → 1-(8-Chloro-7-isopropoxy-4-isopropyl-2,2-dimethyl-2H-chromene-6-yl)-propan-1-one

HRID 2180538Notes

Reaction equation

HRID 2180538 reaction equation
[Cl:1][C:2]1[C:3]([O:21][CH:22]([CH3:24])[CH3:23])=[C:4]([CH:17]([OH:20])[CH2:18][CH3:19])[CH:5]=[C:6]2[C:11]=1[O:10][C:9]([CH3:13])([CH3:12])[CH:8]=[C:7]2[CH:14]([CH3:16])[CH3:15].C[N+]1([O-])CCOCC1>>[Cl:1][C:2]1[C:3]([O:21][CH:22]([CH3:23])[CH3:24])=[C:4]([C:17](=[O:20])[CH2:18][CH3:19])[CH:5]=[C:6]2[C:11]=1[O:10][C:9]([CH3:12])([CH3:13])[CH:8]=[C:7]2[CH:14]([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 82029Methyl morpholine oxideHCID 224908381-(8-Chloro-7-isopropoxy-4-isopropyl-2,2-dimethyl-2H-chromene-6-yl)-propan-1-ol2×

Product 1

HCID 224907671-(8-Chloro-7-isopropoxy-4-isopropyl-2,2-dimethyl-2H-chromene-6-yl)-propan-1-one

Procedure

Following General Procedure M, 1-(8-chloro-7-isopropoxy-4-isopropyl-2,2-dimethyl-2H-chromene-6-yl)-propan-1-ol (Compound 139, 1.05 g, 2.96 mmol) and 4-methylmorpholine N-oxide (520 mg, 4.44 mmol) were reacted to give the title compound as a yellow oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-8224b6ea7a1e4d2d8a1f3f2d12f6e0e7
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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