Sodium Hydroxide → HCID 22491092, compound

HRID 2180549Notes

Reaction equation

HRID 2180549 reaction equation
[Cl:1][C:2]1[C:3]([O:31][CH3:32])=[C:4](/[C:17](/[CH3:30])=[C:18](/[F:29])\[CH:19]=[CH:20]\[C:21](\[CH3:28])=[CH:22]\[C:23]([O:25]CC)=[O:24])[CH:5]=[C:6]2[C:11]=1[O:10][C:9]([CH3:13])([CH3:12])[CH:8]=[C:7]2[CH:14]([CH3:16])[CH3:15].[OH-].[Na+]>C(O)C.C1COCC1>[Cl:1][C:2]1[C:3]([O:31][CH3:32])=[C:4](/[C:17](/[CH3:30])=[C:18](/[F:29])\[CH:19]=[CH:20]\[C:21](\[CH3:28])=[CH:22]\[C:23]([OH:25])=[O:24])[CH:5]=[C:6]2[C:11]=1[O:10][C:9]([CH3:12])([CH3:13])[CH:8]=[C:7]2[CH:14]([CH3:15])[CH3:16]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 87973260HCID 87973260, compound2×

Product 1

HCID 22491092HCID 22491092, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

Following General Procedure G, a solution of ethyl 7-(8-chloro-4-isopropyl-7-methoxy-2,2-dimethyl-2H-chromen-6-yl)-6-fluoro-3-methyl-octa-2E,4E,6E-trienoate (Compound 164, 38 mg, 0.082 mmol) in ethanol and THF was hydrolyzed with 1M NaOH to give rise to the title compound as a white solid.

Sources & evidence

ORD record
ord-c753bc8c1a194b49a0e4d94a50b73642
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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