Diisobutylaluminumhydride → HCID 22491046, compound

HRID 2180571Notes

Reaction equation

HRID 2180571 reaction equation
[CH2:1]([O:3][C:4]1[C:5](/[C:18](/[CH2:26][CH3:27])=[C:19](/[F:25])\[C:20](OCC)=[O:21])=[CH:6][C:7]2[C:8]([CH2:16][CH3:17])=[CH:9][CH2:10][C:11]([CH3:15])([CH3:14])[C:12]=2[CH:13]=1)[CH3:2].[H-].C([Al+]CC(C)C)C(C)C>C1(C)C=CC=CC=1>[CH2:1]([O:3][C:4]1[C:5](/[C:18](/[CH2:26][CH3:27])=[C:19](/[F:25])\[CH2:20][OH:21])=[CH:6][C:7]2[C:8]([CH2:16][CH3:17])=[CH:9][CH2:10][C:11]([CH3:15])([CH3:14])[C:12]=2[CH:13]=1)[CH3:2]

Participants

4

Reactant 2

HCID 21225700DiisobutylaluminumhydrideHCID 86597840HCID 86597840, compound

Product 1

HCID 22491046HCID 22491046, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Following General Procedure G-1, ethyl (2E)-3-(3-ethoxy-8-ethyl-5,5-dimethyl-5,6-dihydro-naphthalen-2-yl)-2-fluoro-pent-2-enoate (Compound A-42, 42 mg, 0.11 mmol) in toluene (2 mL) and diisobutylaluminum hydride (1.0 M in hexane, 0.48 mL, 0.48 mmol) were reacted to give the title compound after purification by flash chromatography (silica gel, 2.5% ethyl acetate in hexanes).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-ab857a13b88247b9baffc9b3894066cd
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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