Sodium Hydroxide → HCID 22490818, compound

HRID 2180587Notes

Reaction equation

HRID 2180587 reaction equation
[CH2:1]([O:3][C:4]1[C:5](/[C:18](/[CH2:31][CH3:32])=[C:19](/[F:30])\[CH:20]=[CH:21]\[C:22](\[CH3:29])=[CH:23]\[C:24]([O:26]CC)=[O:25])=[CH:6][C:7]2[C:8]([CH2:16][CH3:17])=[CH:9][CH2:10][C:11]([CH3:15])([CH3:14])[C:12]=2[CH:13]=1)[CH3:2].[OH-].[Na+]>C(O)C>[CH2:1]([O:3][C:4]1[C:5](/[C:18](/[CH2:31][CH3:32])=[C:19](/[F:30])\[CH:20]=[CH:21]\[C:22](\[CH3:29])=[CH:23]\[C:24]([OH:26])=[O:25])=[CH:6][C:7]2[C:8]([CH2:16][CH3:17])=[CH:9][CH2:10][C:11]([CH3:15])([CH3:14])[C:12]=2[CH:13]=1)[CH3:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86597849HCID 86597849, compound

Product 1

HCID 22490818HCID 22490818, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following General Procedure J-1, ethyl (2E,4E,6E)-7-(3-ethoxy-8-ethyl-5,5-dimethyl-5,6-dihydro-naphthalen-2-yl)-6-fluoro-3-methyl-nona-2,4,6-trienoate (Compound A-69, 34 mg, 0.077 mmol) in ethanol (2 mL) was hydrolyzed with 1M NaOH to yield the title compound as a yellow solid after purification by flash column chromatography (silica gel, 3% to 50% ethyl acetate in hexane).

Sources & evidence

ORD record
ord-6312dce03b7a45d49cb1e2e3bbc595f6
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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