Sodium Hydroxide → HCID 22490818, compound

Participants

Reaction Steps

Following General Procedure J-1, ethyl (2E,4E,6E)-7-(3-ethoxy-8-ethyl-5,5-dimethyl-5,6-dihydro-naphthalen-2-yl)-6-fluoro-3-methyl-nona-2,4,6-trienoate (Compound A-69, 34 mg, 0.077 mmol) in ethanol (2 mL) was hydrolyzed with 1M NaOH to yield the title compound as a yellow solid after purification by flash column chromatography (silica gel, 3% to 50% ethyl acetate in hexane).

Provenance & Evidence