Sodium Hydroxide → HCID 60003039, compound

Participants

Reaction Steps

As described in General Procedure J-1, ethyl (2E,4E,6E)-7-(8-tert-butyl-3-ethoxy-5,5-dimethyl-5,6-dihydronaphthalen-2-yl)-6-fluoro-3-methyl-nona-2,4,6-trienoate (Compound A-74, 520 mg, 1.111 mmol) in THF (5 mL) and ethanol (5 mL) was hydrolyzed with 1.5 N NaOH (5 mL) to produce the title compound as a yellow solid after purification by recrystallization from acetonitrile.

Provenance & Evidence