Sodium Hydroxide → HCID 60003039, compound

HRID 2180588Notes

Reaction equation

HRID 2180588 reaction equation
[C:1]([C:5]1[C:14]2[CH:13]=[C:12](/[C:15](/[CH2:28][CH3:29])=[C:16](/[F:27])\[CH:17]=[CH:18]\[C:19](\[CH3:26])=[CH:20]\[C:21]([O:23]CC)=[O:22])[C:11]([O:30][CH2:31][CH3:32])=[CH:10][C:9]=2[C:8]([CH3:34])([CH3:33])[CH2:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+]>C1COCC1.C(O)C>[C:1]([C:5]1[C:14]2[CH:13]=[C:12](/[C:15](/[CH2:28][CH3:29])=[C:16](/[F:27])\[CH:17]=[CH:18]\[C:19](\[CH3:26])=[CH:20]\[C:21]([OH:23])=[O:22])[C:11]([O:30][CH2:31][CH3:32])=[CH:10][C:9]=2[C:8]([CH3:33])([CH3:34])[CH2:7][CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 86597850HCID 86597850, compound

Product 1

HCID 60003039HCID 60003039, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

As described in General Procedure J-1, ethyl (2E,4E,6E)-7-(8-tert-butyl-3-ethoxy-5,5-dimethyl-5,6-dihydronaphthalen-2-yl)-6-fluoro-3-methyl-nona-2,4,6-trienoate (Compound A-74, 520 mg, 1.111 mmol) in THF (5 mL) and ethanol (5 mL) was hydrolyzed with 1.5 N NaOH (5 mL) to produce the title compound as a yellow solid after purification by recrystallization from acetonitrile.

Sources & evidence

ORD record
ord-0ab746b1a8a54544821ea4fdffcb386e
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

Loading…