1-Methylpiperazine → 4-(N-methylpiperazinyl)butylphthalimide

HRID 21806Notes

Reaction equation

HRID 21806 reaction equation
BrCC[C:4]1[CH:5]=[C:6]2[C:11](=[O:12])[NH:10][C:8](=[O:9])[C:7]2=[CH:13][CH:14]=1.[CH3:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>C(OCC)C>[CH3:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH:17]1[CH2:5][CH2:4][CH2:14][CH2:13][C:5]1[CH:4]=[CH:14][CH:13]=[C:7]2[C:8]([NH:10][C:11](=[O:12])[C:6]=12)=[O:9]

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 541597404-Bromoethylphthalimide

Product 1

HCID 538263884-(N-methylpiperazinyl)butylphthalimide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

4-Bromoethylphthalimide (564 mg; 2.0 mmoles) and N-methylpiperazine (0.44 ml; 4.0 mmoles) were dissolved in anhydrous ethyl ether (5 ml). Reaction times and process as per Example 1.

Workup

  1. customReaction times and process as per Example 1

Sources & evidence

ORD record
ord-71e839f9177c4648a87ff24581292fe1
Source dataset
uspto-grants-1995_06
Patent number
US05424451

Reaction notes

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