Sodium Hydroxide → HCID 22490777, compound

HRID 2180634Notes

Reaction equation

HRID 2180634 reaction equation
[Br:1][C:2]1[C:11]2[C:10]([CH3:13])([CH3:12])[CH2:9][CH:8]=[C:7]([CH:14]([CH3:16])[CH3:15])[C:6]=2[CH:5]=[C:4](/[C:17](/[CH3:30])=[C:18](/[F:29])\[CH:19]=[CH:20]\[C:21](\[CH3:28])=[CH:22]\[C:23]([O:25]CC)=[O:24])[C:3]=1[O:31][CH2:32][CH3:33].[OH-].[Na+]>C(O)C>[Br:1][C:2]1[C:11]2[C:10]([CH3:13])([CH3:12])[CH2:9][CH:8]=[C:7]([CH:14]([CH3:16])[CH3:15])[C:6]=2[CH:5]=[C:4](/[C:17](/[CH3:30])=[C:18](/[F:29])\[CH:19]=[CH:20]\[C:21](\[CH3:28])=[CH:22]\[C:23]([OH:25])=[O:24])[C:3]=1[O:31][CH2:32][CH3:33]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86759717HCID 86759717, compound2×

Product 1

HCID 22490777HCID 22490777, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

As described in General Procedure J-1, ethyl (2E,4E,6E)-7-(4 bromo-3-ethoxy-8-isopropyl-5,5-dimethyl-5,6-dihydro-naphthalen-2-yl)-6 fluoro-3-methyl-octa-2,4,6-trienoate (Compound A-158, 860 mg, 1.65 mmol) in ethanol was treated with a solution of 1 N NaOH to produce the title compound after purification by recrystallization from acetonitrile.

Sources & evidence

ORD record
ord-40277213822e479196520c180b39a62f
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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