N-Phenylacetyl-L-leucine → HCID 15481774, compound

HRID 2180736Notes

Reaction equation

HRID 2180736 reaction equation
[C:1]1([CH2:7][C:8]([NH:10][C@H:11]([C:16]([OH:18])=[O:17])[CH2:12][CH:13]([CH3:15])[CH3:14])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(Cl)(Cl)Cl.C(O)C(C)C>[CH2:2]([O:17][C:16](=[O:18])[C@H:11]([CH2:12][CH:13]([CH3:15])[CH3:14])[NH:10][C:8](=[O:9])[CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[CH:1]([CH3:7])[CH3:6]

Participants

4

Reactant 1

HCID 11983894N-Phenylacetyl-L-leucine

Product 1

HCID 15481774HCID 15481774, compound

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 6560IsobutanolSolvent

Procedure

N-Phenylacetyl-L-leucine (0.0081 g, 0.038 mmol) was dissolved in 2.0 MI, CHCl3 (EtOH free) and iso-butyl alcohol (0.055 mL) and treated with P-EPC (100 mg, 0.87 milliequivalents). The mixture was rotated for 4 days, filtered through a plug of cotton and the filtrate evaporated at reduced pressure to an oil which was sufficiently pure for testing.

Workup

  1. additiontreated with P-EPC (100 mg, 0.87 milliequivalents)
  2. filtrationfiltered through a plug of cotton
  3. customthe filtrate evaporated at reduced pressure to an oil which

Sources & evidence

ORD record
ord-a3693a84db4748878bdad458e1276728
Source dataset
uspto-grants-2005_05
Patent number
US06888022B2

Reaction notes

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