1-Methylpiperazine → 6-(N-methylpiperazinyl)hexylphthalimide

HRID 21808Notes

Reaction equation

HRID 21808 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]1[CH:18]=[CH:17][CH:16]=[C:10]2[C:11]([NH:13][C:14](=[O:15])[C:9]=12)=[O:12].[CH3:19][N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>C(OCC)C>[CH3:19][N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH:21]1[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]1[CH:18]=[CH:17][CH:16]=[C:10]2[C:11]([NH:13][C:14](=[O:15])[C:9]=12)=[O:12]

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 219308536-Bromohexylphthalimide

Product 1

HCID 544966336-(N-methylpiperazinyl)hexylphthalimide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

6-Bromohexylphthalimide (460 mg; 2.0 mmoles) and N-methylpiperazine (0.44 ml; 4.0 mmoles) were dissolved in anhydrous ethyl ether (5 ml). Reaction times and process as per Example 1.

Workup

  1. customReaction times and process as per Example 1

Sources & evidence

ORD record
ord-4993fdf01cd64c2ebaa1515a66412e30
Source dataset
uspto-grants-1995_06
Patent number
US05424451

Reaction notes

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