Hydrochloric Acid → HCID 66921046, compound

HRID 218081Notes

Reaction equation

HRID 218081 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[C:12]1[N:13]=[C:14]([N:17]2[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]2)[S:15][CH:16]=1)[C:5]([O:7]C)=[O:6].[ClH:24]>>[ClH:24].[F:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[C:12]1[N:13]=[C:14]([N:17]2[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]2)[S:15][CH:16]=1)[C:5]([OH:7])=[O:6]

Participants

3

Reactant 2

HCID 313Hydrochloric Acid2×HCID 57551991HCID 57551991, compound

Product 1

HCID 66921046HCID 66921046, compound

Conditions

Temperature
90 °C

Procedure

The methyl ester (1.76 g, 5.25 mmol) (9d) was heated at 80° C. with 6M HCl (40 mL) for 5.5 h. More 6M HCl (10 mL) was added and the mixture was heated at 90° C. for 1 h 15 min. After cooling, the mixture was then evaporated under vacuum and freeze-dried from water to give the final product as cream solids in quantitative yield.

Workup

  1. temperatureAfter cooling
  2. customthe mixture was then evaporated under vacuum
  3. dry with materialfreeze-dried from water

Sources & evidence

ORD record
ord-538152257a5745099591823fead48612
Source dataset
uspto-grants-2012_06
Patent number
US08198283B2

Reaction notes

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