1,4-Dioxane hydrochloride → HCID 86589112, compound

Participants

Reaction Steps

The tris[4-(β-benzyloxycarbonylaminomethyl-N-t-butoxycarbonyl-L-alanyl)aminophenyl]methane (the total amount obtained in the previous reaction) was dissolved in tetrahydrofuran (4 mL), and a hydrochloric acid/dioxane solution (2 N, 4 mL) was added while cooling on ice. The mixture was raised to room temperature and stirred for 4 hours, and then concentrated under reduced pressure to obtain the title compound.

Provenance & Evidence