1,4-Dioxane hydrochloride → HCID 86589112, compound

HRID 2180865Notes

Reaction equation

HRID 2180865 reaction equation
[CH2:1]([O:8][C:9]([NH:11][CH2:12][CH2:13][C@@H:14]([C:23]([NH:25][C:26]1[CH:31]=[CH:30][C:29]([CH:32]([C:64]2[CH:69]=[CH:68][C:67]([NH:70][C:71](=[O:94])[C@H:72]([CH2:81][CH2:82][NH:83][C:84]([O:86][CH2:87][C:88]3[CH:93]=[CH:92][CH:91]=[CH:90][CH:89]=3)=[O:85])[NH:73]C(OC(C)(C)C)=O)=[CH:66][CH:65]=2)[C:33]2[CH:38]=[CH:37][C:36]([NH:39][C:40](=[O:63])[C@H:41]([CH2:50][CH2:51][NH:52][C:53]([O:55][CH2:56][C:57]3[CH:62]=[CH:61][CH:60]=[CH:59][CH:58]=3)=[O:54])[NH:42]C(OC(C)(C)C)=O)=[CH:35][CH:34]=2)=[CH:28][CH:27]=1)=[O:24])[NH:15]C(OC(C)(C)C)=O)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:95].O1CCOCC1>O1CCCC1>[ClH:95].[CH2:1]([O:8][C:9]([NH:11][CH2:12][CH2:13][C@@H:14]([C:23]([NH:25][C:26]1[CH:27]=[CH:28][C:29]([CH:32]([C:64]2[CH:69]=[CH:68][C:67]([NH:70][C:71](=[O:94])[C@H:72]([CH2:81][CH2:82][NH:83][C:84]([O:86][CH2:87][C:88]3[CH:89]=[CH:90][CH:91]=[CH:92][CH:93]=3)=[O:85])[NH2:73])=[CH:66][CH:65]=2)[C:33]2[CH:38]=[CH:37][C:36]([NH:39][C:40](=[O:63])[C@H:41]([CH2:50][CH2:51][NH:52][C:53]([O:55][CH2:56][C:57]3[CH:62]=[CH:61][CH:60]=[CH:59][CH:58]=3)=[O:54])[NH2:42])=[CH:35][CH:34]=2)=[CH:30][CH:31]=1)=[O:24])[NH2:15])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 20779499HCID 20779499, compound

Product 1

HCID 86589112HCID 86589112, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The tris[4-(β-benzyloxycarbonylaminomethyl-N-t-butoxycarbonyl-L-alanyl)aminophenyl]methane (the total amount obtained in the previous reaction) was dissolved in tetrahydrofuran (4 mL), and a hydrochloric acid/dioxane solution (2 N, 4 mL) was added while cooling on ice. The mixture was raised to room temperature and stirred for 4 hours, and then concentrated under reduced pressure to obtain the title compound.

Workup

  1. temperaturewhile cooling on ice
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-5cbc7eeae9e748319d1babccf55366cc
Source dataset
uspto-grants-2005_05
Patent number
US06887890B2

Reaction notes

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