1-Ethylpiperazine → HCID 9858469, compound

HRID 2180913Notes

Reaction equation

HRID 2180913 reaction equation
[F:1][C:2]1[CH:17]=[CH:16][C:5]2[O:6][C:7]3[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=3[C:9](=O)[NH:10][C:4]=2[CH:3]=1.[CH2:18]([N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)[CH3:19]>>[F:1][C:2]1[CH:17]=[CH:16][C:5]2[O:6][C:7]3[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=3[C:9]([N:23]3[CH2:24][CH2:25][N:20]([CH2:18][CH3:19])[CH2:21][CH2:22]3)=[N:10][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 791961-EthylpiperazineHCID 224840598-fluoro-10H-dibenzo[b,f][1,4]oxazepin-11-one

Product 1

HCID 9858469HCID 9858469, compound

Procedure

Prepared in the same manner as Example 1 starting with 8-fluoro-10H-dibenzo[b,f][1,4]oxazepin-11-one (2, X=O, R1=F) with 1-ethyl piperazine. This compound was an oil with 1H NMR (400 MHz, CDCl3), 1.16 (t, 3H, J=7.2 Hz, CH3), 2.55 (q, 2H, J=7.2 Hz, —CH2—), 2.55-2.65 (broad s, 4H, piperazinyl CH2) 3.55-3.65 (broad s, 4H, piperazinyl CH2), 6.64 (ddd, 1H, J=2.4, 6.6 and 7.2 Hz), 6.82 (dd, 1H, J=2.1 and 7.5 Hz), 7.12 (dd, 1H, J=4.2 and 6.2 Hz), 7.21 (doublet of triplets, 1H, J=0.8 and 6.0 Hz), 7.23 (dd, 1H, J=0.9 and 6.3 Hz), 7.34 (dd, 1H, J=1.2 and 5.7 Hz), 7.44 (doublet of triplets, 1H, J=1.2 and 6.0 Hz).

Sources & evidence

ORD record
ord-5dee9a3c56fa4ea28db0d7660d0d9a09
Source dataset
uspto-grants-2005_05
Patent number
US06890919B2

Reaction notes

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