Trifluoroacetic acid methylene chloride → HCID 11818309, compound

HRID 2180952Notes

Reaction equation

HRID 2180952 reaction equation
[CH:1]1[CH:2]=[CH:3][C:4]2[N:11]=[CH:10][NH:9][C:7](=[O:8])[C:5]=2[CH:6]=1.F[C:13](F)(F)[C:14](O)=O.C(Cl)Cl>>[NH2:9][CH2:7][CH2:5][CH2:4][N:9]1[C:7](=[O:8])[C:5]2[C:4](=[CH:3][CH:2]=[CH:1][CH:6]=2)[N:11]=[C:10]1[C:14]1[CH:13]=[CH:3][CH:2]=[CH:1][CH:6]=1

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 1354087534(1H)-Quinazolinone

Product 1

HCID 11818309HCID 11818309, compound

Procedure

100 mg of resin (7) is suspended in 2 ml of a 50% trifluoroacetic acid/methylen chloride solution and shaken for 1.5 hours at room temperature. Customary working up for solid-phase reactions afforded 3-(3-aminopropyl)-2-phenyl-3H-quinazolin-4-one;

Sources & evidence

ORD record
ord-5d018b0faa3743b48f291368ca1604fb
Source dataset
uspto-grants-2005_05
Patent number
US06890930B1

Reaction notes

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