Hydrochloric Acid → HCID 135856766, compound

HRID 2181003Notes

Reaction equation

HRID 2181003 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:13]2[CH2:18][CH2:17][N:16]([CH3:19])[CH2:15][CH2:14]2)(=[O:12])=[O:11])=[CH:6][C:5]=1[C:20]1[NH:25][C:24](=[O:26])[C:23]2=[C:27]([CH2:33][CH3:34])[N:28]=[C:29]([CH2:30][CH2:31][CH3:32])[N:22]2[N:21]=1)[CH3:2].[ClH:35]>CCOCC.ClCCl>[ClH:35].[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:13]2[CH2:14][CH2:15][N:16]([CH3:19])[CH2:17][CH2:18]2)(=[O:12])=[O:11])=[CH:6][C:5]=1[C:20]1[NH:25][C:24](=[O:26])[C:23]2=[C:27]([CH2:33][CH3:34])[N:28]=[C:29]([CH2:30][CH2:31][CH3:32])[N:22]2[N:21]=1)[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 1355441592-[2-Ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-5-ethyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one

Product 1

HCID 135856766HCID 135856766, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolvent2×HCID 6344DichloromethaneSolvent

Procedure

300 mg (0.61 mmol) of 2-[2-ethoxy-5-(4-methyl-piperazine-1-sulphonyl)-phenyl]-5-ethyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one are dissolved in a mixture of ether and dichloromethane and admixed with 2 ml of a 1M solution of HCl in ether. After 20 minutes, the precipitated solid is filtered off with suction and dried.

Workup

  1. filtrationthe precipitated solid is filtered off with suction
  2. customdried

Sources & evidence

ORD record
ord-80766c46d17841a1964ca2112b0004d2
Source dataset
uspto-grants-2005_05
Patent number
US06890922B2

Reaction notes

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