6-methylpyridine-2-sulfonamide → HCID 76169160, compound

HRID 2181100Notes

Reaction equation

HRID 2181100 reaction equation
CC1(C)[O:6][C:5](=[CH:7][C:8]([N:10]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)[O:11][CH3:12])=[O:9])[C:4](=[O:21])O1.[CH3:23][C:24]1[N:29]=[C:28]([S:30]([NH2:33])(=[O:32])=[O:31])[CH:27]=[CH:26][CH:25]=1>>[F:20][C:17]1[CH:16]=[CH:15][C:14]([CH2:13][N:10]([O:11][CH3:12])[C:8](=[O:9])[CH:7]=[C:5]([OH:6])[C:4]([NH:33][S:30]([C:28]2[CH:27]=[CH:26][CH:25]=[C:24]([CH3:23])[N:29]=2)(=[O:32])=[O:31])=[O:21])=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 8194426-methylpyridine-2-sulfonamideHCID 730332332-(2,2-Dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-N-(4-fluoro-benzyl)-N-methoxy-acetamide

Product 1

HCID 76169160HCID 76169160, compound

Procedure

2-(2,2-Dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-N-(4-fluoro-benzyl)-N-methoxy-acetamide was treated with 6-methyl-pyridine-2-sulfonic acid amide as described in the preparation of compound 1 to yield the title compound. 1H NMR (500 MHz, CDCl3) δ: 2.45 (s, 3), 3.61 (s, 3), 4.73 (s, 2), 6.38 (s, 1), 6.97 (m, 2), 7.23 (m, 2), 7.77 (m, 1), 8.17 (m, 1), 8.54 (s, 1). 13C NMR (125 MHz, CDCl3) δ: 18.71, 48.22, 63.10, 92.48, 115.65, 115.82, 124.67, 130.24, 130.34, 131.09, 138.70, 139.36, 150.54, 152.19, 159.14, 161.66, 163.62, 170.80.

Sources & evidence

ORD record
ord-dcafdfdb349640d0bdb3ae03ce46da85
Source dataset
uspto-grants-2005_05
Patent number
US06890942B2

Reaction notes

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