5-Chlorothiophene-2-Sulfonamide → HCID 72613072, compound

HRID 2181101Notes

Reaction equation

HRID 2181101 reaction equation
CC1(C)[O:6][C:5](=[CH:7][C:8]([N:10]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)[O:11][CH3:12])=[O:9])[C:4](=[O:21])O1.[Cl:23][C:24]1[S:28][C:27]([S:29]([NH2:32])(=[O:31])=[O:30])=[CH:26][CH:25]=1>>[F:20][C:17]1[CH:16]=[CH:15][C:14]([CH2:13][N:10]([O:11][CH3:12])[C:8](=[O:9])[CH:7]=[C:5]([OH:6])[C:4]([NH:32][S:29]([C:27]2[S:28][C:24]([Cl:23])=[CH:25][CH:26]=2)(=[O:31])=[O:30])=[O:21])=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 12413015-Chlorothiophene-2-SulfonamideHCID 730332332-(2,2-Dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-N-(4-fluoro-benzyl)-N-methoxy-acetamide

Product 1

HCID 72613072HCID 72613072, compound

Procedure

2-(2,2-Dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-N-(4-fluoro-benzyl)-N-methoxy-acetamide was treated with 5-chloro-thiophene-2-sulfonic acid amide as described in the preparation of compound 1 to yield the title compound. 1H NMR (500 MHz, CDCl3) δ: 3.66 (s, 3), 4.77 (s, 2), 6.49 (s, 1), 7.00 (overlapping m, 3), 7.26 (m, 2), 7.72 (m, 1). 13C NMR (125 MHz, CDCl3) δ: 48.29, 63.20, 92.61, 115.69, 115.87, 126.94, 130.23, 130.30, 131.01, 135.19, 135.85, 140.50, 159.01, 159.08, 161.69, 163.66, 170.84.

Sources & evidence

ORD record
ord-9d2c043e67f14c90a8d97410dee35e17
Source dataset
uspto-grants-2005_05
Patent number
US06890942B2

Reaction notes

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