4'-Fluoroacetophenone → HCID 72613054, compound

HRID 2181127Notes

Reaction equation

HRID 2181127 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH3:9])=[CH:4][CH:3]=1.Cl.[O:12]([NH2:14])[CH3:13]>>[CH3:13][O:12][N:14]=[C:8]([C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1)[CH3:9]

Participants

3

Reactant 2

HCID 98284'-FluoroacetophenoneHCID 521874O-Methylhydroxylamine hydrochloride

Product 1

HCID 72613054HCID 72613054, compoundYield 92%

Procedure

Reaction of 4′-fluoroacetophenone with methoxylamine hydrochloride as described in the preparation of compound 1-A gave the title oxime ether as a clear oil (92% yield). 1HNMR indicated a 87:13 mixture of E and Z isomers. 1HNMR 400 MHz (CDCl3) δ (ppm): (E-isomer) 2.21 (3H, s, CH3), 3.99 (3H, s, OCH3), 7.04 (2H, m, aromatics), 7.63 (2H, m, aromatics).

Sources & evidence

ORD record
ord-99fa27be790d427fbf117aae2105970d
Source dataset
uspto-grants-2005_05
Patent number
US06890942B2

Reaction notes

Loading…