反应详情

In analogy to the procedures described in preparation 1a) and 1b), 3-methyl-1H-indole-5-carbaldehyde [Helv. Chim. Acta (1968), 51(7), 1616-28] was reacted with (1,2-diethoxy-2-oxoethyl)triphenyl phosphonium chloride in dichloromethane in the presence of tetramethyl guanidine to give.(Z)-2-ethoxy-3-(3-methyl-1H-indol-5-yl)-acrylic acid ethyl ester, which was subsequently hydrogenated to yield the title compound as colorless oil.

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