HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1,3,3-Tetramethylguanidine → HCID 69563048, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1,3,3-Tetramethylguanidine | HCID 66460 | — |
| Reactant | Phosphonium, (1,2-diethoxy-2-oxoethyl)triphenyl-, chloride (1:1) | HCID 11327835 | — |
| Reactant | 3-methyl-1H-indole-5-carbaldehyde | HCID 22485678 | — |
| Reactant | HCID 69563611 | HCID 69563611 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 69563048 | HCID 69563048 | — |
Reaction Steps
In analogy to the procedures described in preparation 1a) and 1b), 3-methyl-1H-indole-5-carbaldehyde [Helv. Chim. Acta (1968), 51(7), 1616-28] was reacted with (1,2-diethoxy-2-oxoethyl)triphenyl phosphonium chloride in dichloromethane in the presence of tetramethyl guanidine to give.(Z)-2-ethoxy-3-(3-methyl-1H-indol-5-yl)-acrylic acid ethyl ester, which was subsequently hydrogenated to yield the title compound as colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06890947B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-4211262c41624143b722d76f3d459428 |
| Source note | uspto-grants-2005_05 |